Article

Tumor cell p38 inhibition to overcome immunotherapy resistance

2023-08-19

Abstract excerpt

<title>Abstract</title> <p>Patients with tumors that do not respond to immune-checkpoint inhibition often harbor a non-T cell-inflamed tumor microenvironment, characterized by the absence of IFN-γ-associated CD8+ T cell and dendritic cell activation. Understanding the molecular mechanisms underlying immune exclusion in non-responding patients may enable the development of novel combination therapies. p38 MAPK is...

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Literature Corpus work: 7171f7a5-f1fd-530c-9a3a-1a1481230449
DOI: 10.21203/rs.3.rs-3183496/v1

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