Article

Heightened virulence of <i>Yersinia</i> is associated with decreased function of the YopJ protein

2021-03-22

Abstract excerpt

Despite the maintenance of YopP/J alleles throughout the human-pathogenic Yersinia lineage, the benefit of YopP/J-induced phagocyte death for Yersinia pathogenesis in animals is not obvious. To determine how sequence divergence of YopP/J has impacted Yersinia virulence, we examined protein polymorphisms in this Type III secreted effector protein across 17 Yersinia species, and tested the consequences of polymo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d1aef2d-0d0d-552f-88cc-74ca3b0c5da2
DOI: 10.1101/2021.03.22.436461

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Heightened virulence of <i>Yersinia</i> is associated with decreased function of the YopJ proteinDOI 10.1101/2021.03.22.436461Read

Heightened Virulence of Yersinia Is Associated with Decreased Function of the YopJ Protein.Semantic proximity Read

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.Semantic proximity Read

Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.Semantic proximity Read

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.Semantic proximity Read

Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death.Semantic proximity Read

Delineation of Regions of the<i>Yersinia</i>YopM Protein Required for Interaction with the RSK1 and PRK2 Host Kinases and Their Requirement for Interleukin-10 Production and VirulenceSemantic proximity Read

YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK.Semantic proximity Read

Pathogenesis of<i>Y. enterocolitica</i>and<i>Y. pseudotuberculosis</i>in Human YersiniosisSemantic proximity Read

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.Semantic proximity Read

The Small RNA Chaperone Hfq Is Required for the Virulence of <i>Yersinia pseudotuberculosis</i>Semantic proximity Read

Coiled-coils in the YopD translocator family: a predicted structure unique to the YopD N-terminus contributes to full virulence of Yersinia pseudotuberculosis.Semantic proximity Read

Yersinia pseudotuberculosis YopD mutants that genetically separate effector protein translocation from host membrane disruption.Semantic proximity Read