Article
YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK.
Molecular microbiology - 1 Mar 1998
Palmer L E, Hobbie S, Galán J E, Bliska J B
Abstract excerpt
Exposure of macrophages to lipopolysaccharide (LPS) leads to production of the pro-inflammatory cytokine, tumour necrosis factor alpha (TNF-alpha). Previous studies have suggested that pathogenic Yersinia spp. inhibit LPS-mediated production of TNF-alpha in macrophages, and that one of the Yop pr...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cloning, Molecular
- Down-Regulation
- Enzyme Activation
- Gene Expression Regulation, Bacterial
- Genetic Complementation Test
- Immunoblotting
- JNK Mitogen-Activated Protein Kinases