Article
Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Monack D M, Mecsas J, Ghori N, Falkow S
Abstract excerpt
Pathogenic Yersinia spp. carry a large common plasmid that encodes a number of essential virulence determinants. Included in these factors are the Yersinia-secreted proteins called Yops. We analyzed the consequences of wild-type and mutant strains of Yersinia pseudotuberculosis interactions with the macrophage cell line RAW264. 7 and murine bone marrow-derived macrophages. Wild-type Y. pseudotuberculosis kills...
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