Article

β3 accelerates microtubule plus end maturation through a divergent lateral interface

2024-07-18

Abstract excerpt

β-tubulin isotypes exhibit similar sequences but different activities, suggesting that limited sequence divergence is functionally important. We investigated this hypothesis for TUBB3/β3, a β-tubulin linked to aggressive cancers and chemoresistance in humans. We created mutant yeast strains with β-tubulin alleles that mimic variant residues in β3 and find that residues at the lateral interface are sufficient to al...

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Literature Corpus work: 6d12c028-0f8f-55f0-8af1-bc07d9b84120
DOI: 10.1101/2024.07.17.603993

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