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Article

A genetic model of ivabradine recapitulates results from randomized clinical trials

2020-02-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Naturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure despite increasing the risk of atrial fibrillation. In patients with coronary artery disease without heart failure, the drug does not protect agains...

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Literature Corpus work
6d017f90-304c-5149-a6b8-ac83f6fdb8a9
DOI
10.1101/2020.01.29.20019521
Open publication

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A genetic model of ivabradine recapitulates results from randomized clinical trialsDOI 10.1101/2020.01.29.20019521
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