Article

ACE inhibition and cardiometabolic risk factors, lung <i>ACE2</i> and <i>TMPRSS2</i> gene expression, and plasma ACE2 levels: a Mendelian randomization study

2020-04-14

Abstract excerpt

<h4>Objectives</h4> To use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to provide insight into how these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. <h4>Design</h4> Two-sample Mendelian randomization (MR) analysis. <h4>Setting</h4> <h4>Summary: </h4> -level genetic association data. <h4>Particip...

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Literature Corpus work: 2d0d062c-256d-5908-8770-2db7335c87ce
DOI: 10.1101/2020.04.10.20059121

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