Article
Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: A preliminary report.
Cardiology journal - 1 Jan 2016
Núñez Lucía, Crespo-Leiro María G, Marrón-Liñares Grecia M, Suarez-Fuentetaja Natalia, Barge-Caballero Eduardo, Paniagua-Martín María Jesús, Marzoa-Rivas Raquel, Grille-Cancela Zulaika, Muñiz-García Javier, Vazquez-Rodriguez Jose Manuel, Hermida-Prieto Manuel
Abstract excerpt
BACKGROUND: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction is 8-10 beats, although clinical trials reveal interindividual variability. The aim of the study is to identify variants associated with HR reduction produced by ivabradine in genes involved in the drug...
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