Article

Combining Genetic Proxies of Drug Targets and Time-to-event analyses From Longitudinal Observational Data To Identify Target Patient Populations

2024-06-05

Abstract excerpt

<h4>Background</h4> Human genetics is an important tool for identifying genes as potential drug targets, and the extensive genetic study of cardiovascular disease provides an opportunity to leverage genetics to match specific patient populations to specific drug targets to improve prioritization of patient selection for clinical studies. <h4>Methods</h4> We selected well described genetic variants in the region of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7ac112f-23d6-5d63-97ac-eb0a699221fe
DOI: 10.1101/2024.06.05.24308448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combining Genetic Proxies of Drug Targets and Time-to-event analyses From Longitudinal Observational Data To Identify Target Patient PopulationsDOI 10.1101/2024.06.05.24308448Read

Combining genetic proxies of drug targets and time-to-event analyses from longitudinal observational data to identify target patient populations.Semantic proximity Read

A genetic model of ivabradine recapitulates results from randomized clinical trialsSemantic proximity Read

The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data.Semantic proximity Read

Calcium Channel Blockers: clinical outcome associations with reported pharmacogenetics variants in 32,000 patientsSemantic proximity Read

A genetic model of ivabradine recapitulates results from randomized clinical trials.Semantic proximity Read

Genetic Variants Associated with Adverse Events after Angiotensin-Converting Enzyme Inhibitor Use: Replication after GWAS-Based Discovery.Semantic proximity Read

Combining pharmacogenetics and patient characteristic polygenic scores to improve outcome prediction for Calcium Channel Blocker treatmentSemantic proximity Read

Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure.Semantic proximity Read

Phenotype-Specific Association of Single-Nucleotide Polymorphisms with Heart Failure and Preserved Ejection Fraction: a Genome-Wide Association Analysis of the Cardiovascular Health Study.Semantic proximity Read

ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.Semantic proximity Read

Pharmacogenetic Risk Stratification in Angiotensin-Converting Enzyme Inhibitor-Treated Patients with Congestive Heart Failure: A Retrospective Cohort Study.Semantic proximity Read

GWAS of amiodarone-induced thyroid dysfunction: Applications for genotype-guided risk stratificationSemantic proximity Read