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Article

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity.

Diabetologia - 1 Oct 2015

Templeman Nicole M, Clee Susanne M, Johnson James D

Abstract excerpt

AIMS/HYPOTHESIS: Hyperinsulinaemia is associated with obesity but its causal role in the onset of obesity remains controversial. In this study, we tested the hypothesis that transient attenuation of diet-induced insulin hypersecretion in young mice can provide sustained protection against obesity throughout adult life. METHODS: Using 'genetically humanised' mice lacking both alleles of rodent-specific Ins1, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26155745
DOI: 10.1007/s00125-015-3676-7
PMCID: PMC4572061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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