Article

Deep Visual Proteomics advances human colon organoid models by revealing a switch to an <i>in vivo</i> -like phenotype upon xenotransplantation

2024-05-14

Abstract excerpt

<h4> Abstract </h4> Intestinal epithelial damage predisposes to chronic disorders like inflammatory bowel disease. The organoid model allows cultivation, expansion and analysis of primary intestinal epithelial cells and has been instrumental in studying epithelial behavior in homeostasis and disease. Recent advances in organoid transplantation allow studying human epithelial cell behavior within the intestinal t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ce5f976-eb9e-5ca7-b5f4-89d25f1d3758
DOI: 10.1101/2024.05.13.593888

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Visual Proteomics advances human colon organoid models by revealing a switch to an <i>in vivo</i> -like phenotype upon xenotransplantationDOI 10.1101/2024.05.13.593888Read

Deep visual proteomics reveals an in vivo-like phenotype of orthotopically transplanted human colon organoids.Semantic proximity Read

Bioengineered human colon organoids with <i>in vivo</i> -like complexity and functionSemantic proximity Read

Bioengineered human colon organoids with in vivo-like cellular complexity and functionSemantic proximity Read

Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and EthicsSemantic proximity Read

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.Semantic proximity Read

Epithelial proteomics in multiple organs and tissues: similarities and variations between cells, organs, and diseases.Semantic proximity Read

Human Organ Chips Reveal New Inflammatory Bowel Disease DriversSemantic proximity Read

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.Semantic proximity Read

Organoids in gastrointestinal diseases: from bench to clinicSemantic proximity Read

A high-fidelity in vitro model of the human intestinal epitheliumSemantic proximity Read

A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized TherapeuticsSemantic proximity Read

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoidsSemantic proximity Read