Article
Deep visual proteomics reveals an in vivo-like phenotype of orthotopically transplanted human colon organoids.
Cell systems - 17 Sept 2025
Post Frederik, Hausmann Annika, Kabatnik Sonja, Steigerwald Sophia, Brand Alexandra, Clement Ditte L, Skov Jonathan, Lõhmussaar Kadi, Larsen Hjalte L, Maimets Martti, Boye Theresa L, Jez Gabriela, Sato Toshiro, Steenholdt Casper, Rosenberger Florian, Mund Andreas, Nielsen Ole H, Jensen Kim B, Mann Matthias
Abstract excerpt
Intestinal epithelial damage predisposes to disorders like inflammatory bowel disease (IBD), with organoid transplantation emerging as a potential treatment. However, it is not known how well organoids recapitulate in vivo intestinal epithelial cells (IECs). We employed deep visual proteomics (DVP), integrating AI-guided cell classification, laser microdissection, and ultra-high-sensitivity proteomics at the...
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