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Article

Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex.

Nature communications - 19 Oct 2020

Bar-El Michal Lisnyansky, Vaňková Pavla, Yeheskel Adva, Simhaev Luba, Engel Hamutal, Man Petr, Haitin Yoni, Giladi Moshe

Abstract excerpt

The human cis-prenyltransferase (hcis-PT) is an enzymatic complex essential for protein N-glycosylation. Synthesizing the precursor of the glycosyl carrier dolichol-phosphate, mutations in hcis-PT cause severe human diseases. Here, we reveal that hcis-PT exhibits a heterotetrameric assembly in solution, consisting of two catalytic dehydrodolichyl diphosphate synthase (DHDDS) and inactive Nogo-B receptor (NgBR)...

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Identifiers

PMID: 33077723
DOI: 10.1038/s41467-020-18970-z
PMCID: PMC7573591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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