Article

Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

2023-09-12

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target because of its dual roles in proliferation and invasion. The clinical utility of KIF11 inhibitors has been limited by drug resistance, which has mainly been studied in animal models. We used multiplexed lineage tracing barcodes and scRNA-seq to analyze drug resistance time courses for patie...

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Literature Corpus work: 6ce1c4d2-8220-580c-a8a1-498be5cdebde
DOI: 10.1101/2023.09.09.557001

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