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Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

21 Apr 2024

Abstract excerpt

Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive therapeutic target with roles in proliferation and invasion. Resistance to KIF11 inhibitors, which has mainly been studied in animal models, presents significant challenges. We use lineage-tracing barcodes and single-cell RNA sequencing to analyze resistance in patient-derived GBM neurospheres treated with ispinesib, a potent...

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PMID: 38652658
DOI: 10.1016/j.celrep.2024.114139

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