Back to search

Article

Fitness costs and benefits in response to artificial artesunate selection in <i>Plasmodium</i>

2022-01-28

Abstract excerpt

<h4> A bstract </h4> Drug resistance is a major issue in the control of malaria. Mutations linked to drug resistance often target key metabolic pathways and are therefore expected to be associated with biological costs. The spread of drug resistance depends on the balance between the benefits that these mutations provide in the drug-treated host and the costs they incur in the untreated host. The latter may the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6ce14e36-41a0-5ece-b179-8e928e1a45d2
DOI
10.1101/2022.01.28.478164
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fitness costs and benefits in response to artificial artesunate selection in <i>Plasmodium</i>DOI 10.1101/2022.01.28.478164
Eco-evolutionary dynamics of <i>Plasmodium</i> genotypes under mass drug administrationSemantic proximity
Impaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies.Semantic proximity
The interplay between drug resistance and fitness in malaria parasitesSemantic proximity
Harnessing evolutionary fitness in <i>Plasmodium falciparum</i> for drug discovery and suppressing resistanceSemantic proximity
Transmissibility of clinically relevant atovaquone-resistant <i>Plasmodium falciparum</i> by anopheline mosquitoesSemantic proximity
<i>pfmdr1</i> mutations associated with chloroquine resistance incur a fitness cost in <i>Plasmodium falciparum</i>Semantic proximity
Seasonal malaria chemoprevention and the spread of<i>Plasmodium falciparum</i>quintuple mutant parasites resistant to sulfadoxine-pyrimethamine: a modelling studySemantic proximity
The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant <i>Plasmodium falciparum</i>Semantic proximity
Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.Semantic proximity
A combined within-host and between-hosts modelling framework for the evolution of resistance to antimalarial drugsSemantic proximity
Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.Semantic proximity
The evolutionary landscape of antifolate resistance in Plasmodium falciparum.Semantic proximity
Select a neighboring publication to make it the new centre.