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Seasonal malaria chemoprevention and the spread of<i>Plasmodium falciparum</i>quintuple mutant parasites resistant to sulfadoxine-pyrimethamine: a modelling study

2023-07-24

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) prevents millions of clinical malaria cases in children under five in Africa’s Sahel region. However, parasites partially resistant to SP (with “quintuple” mutations) potentially threaten SMC protective effectiveness. We evaluated its spread and clinical consequences. <h4>Methods</h...

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Literature Corpus work
cd6481c5-f290-5465-82a6-8d8735045e44
DOI
10.1101/2023.07.23.23293041
Open publication

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Seasonal malaria chemoprevention and the spread of<i>Plasmodium falciparum</i>quintuple mutant parasites resistant to sulfadoxine-pyrimethamine: a modelling studyDOI 10.1101/2023.07.23.23293041
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