Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

20 Feb 2012

Abstract excerpt

The Interferon induced transmembrane proteins (IFITM) are a family of transmembrane proteins that is known to inhibit cell invasion of viruses such as HIV-1 and influenza. We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which refers to a common 2TM structure. We mined the Dispanins in 36 eukaryotic species, covering all major eukaryotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Phylogenetic Studies
Share to Glycosylation and Glycoproteins Research
Share to Influenza Virus Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22363774
DOI: 10.1371/journal.pone.0031961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human MembersPMID 22363774Read ↗

The emerging roles of IFIT3 in antiviral innate immunity and cellular biologySemantic proximity Read ↗

A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathwaySemantic proximity Read ↗

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?Semantic proximity Read ↗

Interferon induced IFIT family genes in host antiviral defense.Semantic proximity Read ↗

IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral InfectionsSemantic proximity Read ↗

The evolutionary landscape of cytosolic microbial sensors in humans.Semantic proximity Read ↗

Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ~500 MYSemantic proximity Read ↗

Evolution of vertebrate interferon inducible transmembrane proteinsSemantic proximity Read ↗

A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatusSemantic proximity Read ↗

New and atypical families of type I interferons in mammals: comparative functions, structures, and evolutionary relationships.Semantic proximity Read ↗

Distinct evolution process among type I interferon in mammalsSemantic proximity Read ↗

Nach is a novel ancestral subfamily ofthe CNC-bZIP transcription factors selected during evolution from the marine bacteria to humanSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.