Article

Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis

2022-06-07

Abstract excerpt

Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required for preventing fatal pathology during T. gondii infection. Here, we report that abrogation of STAT1 signaling in microglia, the resident immune cells of the CNS, is sufficient t...

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Literature Corpus work: d384085d-97bc-5368-8651-e5aae166bb97
DOI: 10.1101/2022.06.06.494970

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