Article

VICAST: An Integrated Toolkit for Viral Genome Annotation Curation and Low-Frequency Variant Analysis in Passage Studies

2026-03-18

Abstract excerpt

Cultured virus passage studies are fundamental to understanding viral evolution, attenuation, and host adaptation, yet analyzing genomic changes across passages requires both accurate functional annotation of viral genomes and sensitive detection of low-frequency variants. Existing tools address these needs separately: automated annotation pipelines such as VADR and VIGOR4 perform well for well-characterized virus...

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Literature Corpus work: 6c60cbaf-508a-53cf-9827-0f804575f80e
DOI: 10.64898/2026.03.16.712174

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