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Article

A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

2022-12-30

Abstract excerpt

Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to genes. This raises the possibility that transcriptional readthrough and intron retention are responsible for age-rela...

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Identifiers and source

Literature Corpus work
6c457aa8-4883-50df-b33e-c97c2ce3882a
DOI
10.1101/2022.12.29.522277
Open publication

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A concerted increase in readthrough and intron retention drives transposon expression during aging and senescenceDOI 10.1101/2022.12.29.522277
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