A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

Abstract excerpt

Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to genes. This raises the possibility that transcriptional readthrough and intron retention are responsible for...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to Chromosomal and Genetic Variations
• Share to Telomeres, Telomerase, and Senescence