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A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

2024-04-03

Abstract excerpt

Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes and introns, with a large minority being close to genes. This raises the possibility that transcriptional readthrough and intron retention are responsible for age-rela...

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Literature Corpus work
3ef469ec-932d-5c55-8640-787410ff992a
DOI
10.7554/elife.87811.3
Open publication

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A concerted increase in readthrough and intron retention drives transposon expression during aging and senescenceDOI 10.7554/elife.87811.3
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