Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.

doi:10.1038/s41598-019-55211-w

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Article

Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.

Scientific reports - 11 Dec 2019

Fujiwara Hiroaki, Tateishi Keisuke, Misumi Kento, Hayashi Akimasa, Igarashi Kaori, Kato Hiroyuki, Nakatsuka Takuma, Suzuki Nobumi, Yamamoto Keisuke, Kudo Yotaro, Hayakawa Yoku, Nakagawa Hayato, Tanaka Yasuo, Ijichi Hideaki, Kogure Hirofumi, Nakai Yosuke, Isayama Hiroyuki, Hasegawa Kiyoshi, Fukayama Masashi, Soga Tomoyoshi, Koike Kazuhiko

Abstract excerpt

Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during tumorigenesis has attracted much attention in cancer research. Recurrent mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes have been identified in several cancers, including intrahepatic cholangiocarcinoma (ICC). Mutant IDHs convert α-ketoglutarate...

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PMID: 31827136
DOI: 10.1038/s41598-019-55211-w
PMCID: PMC6906335

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