Article

Glycolysis-mTORC1 crosstalk drives rapid proliferation in patient-derived endometrial cancer spheroids with ALDH activity

2023-12-05

Abstract excerpt

<title>Abstract</title> <p>Cancer stem cells are associated with aggressive phenotypes of malignant tumors. A prominent feature of uterine endometrial cancer is the activation of the PI3K-Akt-mTOR pathway. Herein, we present variations in sensitivities to a PI3K-Akt-mTORC1 inhibitor among <italic>in vitro</italic> endometrial cancer stem cell-enriched spheroid cells from clinical specimens. Intriguingly, the <ita...

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Literature Corpus work: 8d1015e7-af38-5da0-a742-0d438616b809
DOI: 10.21203/rs.3.rs-3547380/v1

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