Article

Nuclear Fetuin-A Drives Adipocyte Senescence via HIF-1α During Obesity

2025-08-25

Abstract excerpt

Fetuin-A (FetA), a liver derived glycoprotein, has emerged from genome-wide association studies and epidemiological surveillance as a serum biomarker linked to obesity-driven type 2 diabetes mellitus (T2D), primarily due to its contribution to adipose tissue dysfunction. Here, we uncovered an eccentric role of nuclear FetA in visceral white adipocytes of obese T2D conditions. Hypoxia-inducible factor-1α (HIF-1α) f...

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Literature Corpus work: 6c293baa-d750-5090-8e33-effcd7b462c1
DOI: 10.1101/2025.08.18.670856

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