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Article

The fat cell senescence hypothesis

30 May 2014

Abstract excerpt

PURPOSE OF REVIEW: Obesity is a chronic inflammatory disease in which the physiological resolution of inflammation is attenuated, leading to low-grade inflammation throughout the body. However, the heat shock response, which is a key component of the physiological response to resolve inflammation, is seriously hampered in adipose tissue and other metabolic organs (e.g. skeletal muscle, liver, pancreatic β-cells)...

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PMID: 24878874
DOI: 10.1097/mco.0000000000000077

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