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Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress

22 Jan 2021

Abstract excerpt

Intrauterine growth restriction (IUGR) is associated with reduced kidney size at birth, accelerated renal function decline, and increased risk for chronic kidney and cardiovascular diseases in adults. Precise mechanisms underlying fetal programming of adult diseases remain largely elusive and warrant extensive investigation. Setting up a mouse model of hypoxia-induced IUGR, fetal adaptations at mRNA, protein and...

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PMID: 33483479
DOI: 10.1038/s41467-020-20832-7

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