Back to search

Article

Sex-specific remodeling of the human adipose vascular niche in obesity

2026-03-12

Abstract excerpt

<h4> A bstract </h4> Obesity remodels the subcutaneous adipose tissue (SAT) vasculature and contributes to cardiometabolic risk, yet potential sex differences in this process remain poorly defined. Here, we integrated single-nucleus transcriptomics and histological analyses of human SAT to reveal pronounced sexual dimorphism within the vascular niche. Obese males exhibit mural cell loss, increased collagen depo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dab7a882-d06b-53fd-86fb-27a10e40ee6c
DOI
10.64898/2026.03.10.710723
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sex-specific remodeling of the human adipose vascular niche in obesityDOI 10.64898/2026.03.10.710723
The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues agingSemantic proximity
Defining the vascular niche of human adipose tissue across metabolic statesSemantic proximity
A single cell atlas of human and mouse white adipose tissueSemantic proximity
Adipocyte Heterogeneity Underlying Adipose Tissue FunctionsSemantic proximity
Sex Differences in Genomic Drivers of Adipose Distribution and Related Cardiometabolic DisordersSemantic proximity
An integrated single cell and spatial transcriptomic map of human white adipose tissueSemantic proximity
Single-nuclei Transcriptome of Human AT Reveals Metabolically Distinct Depot-Specific Adipose Progenitor SubpopulationsSemantic proximity
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesitySemantic proximity
Master of disguise: deconvoluting adipose tissue heterogeneity and its impact on metabolic healthSemantic proximity
A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissueSemantic proximity
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Semantic proximity
Single-Nuclear RNA Sequencing Reveals Regional Specialization and Cellular Interactions in Epicardial and Perivascular Adipose TissueSemantic proximity
Select a neighboring publication to make it the new centre.