Article

Sex differences in human IgG1-mediated angiogenesis inhibition depend on Y chromosome-encoded DDX3Y

2025-03-29

Abstract excerpt

Prevalent diseases of angiogenesis such as age-related macular degeneration (AMD) exhibit sex-specific prevalence, with female sex being an independent risk factor for the advanced neovascular form of AMD. The basis for these sex differences is poorly understood. Here, we quantify the impact of sex on suppression of aberrant choroidal angiogenesis by human immunoglobulin 1 (hIgG1), which possesses class-wide, anti...

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Identifiers and source

Literature Corpus work: 6c212ea1-ae74-5891-9978-ff156117a703
DOI: 10.1101/2025.03.25.645206

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