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Article

Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration

1 Jan 2024

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of blindness featuring pathogenic neovascularization of the choroidal vasculature (CNV). Although systemic immunity plays a role in AMD, the ocular signals that recruit and activate immune cells remain poorly defined. Using single-cell RNA sequencing, we prospectively profile peripheral blood mononuclear cells from 65 individuals including AMD and...

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PMID: 38232696
DOI: 10.1016/j.xcrm.2023.101353

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