Article

Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer’s disease

2025-01-18

Abstract excerpt

Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, has been implicated in aging and neurodegenerative diseases such as Alzheimer’s disease (AD). While global SIRT2 inhibition has shown promise in reducing amyloid-beta pathology and cognitive deficits in different mouse models of AD, peripheral SIRT2 inhibition has been associated with adverse effects, such as increased inflammation. This suggests that targeted inhib...

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Literature Corpus work: 6c0a8a03-9bbd-51d5-a0e8-4a7b92994062
DOI: 10.1101/2025.01.17.633523

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