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The Human and Mouse Enteric Nervous System at Single-Cell Resolution.

Cell - 17 Sept 2020

Drokhlyansky Eugene, Smillie Christopher S, Van Wittenberghe Nicholas, Ericsson Maria, Griffin Gabriel K, Eraslan Gokcen, Dionne Danielle, Cuoco Michael S, Goder-Reiser Max N, Sharova Tatyana, Kuksenko Olena, Aguirre Andrew J, Boland Genevieve M, Graham Daniel, Rozenblatt-Rosen Orit, Xavier Ramnik J, Regev Aviv

Abstract excerpt

The enteric nervous system (ENS) coordinates diverse functions in the intestine but has eluded comprehensive molecular characterization because of the rarity and diversity of cells. Here we develop two methods to profile the ENS of adult mice and humans at single-cell resolution: RAISIN RNA-seq for profiling intact nuclei with ribosome-bound mRNA and MIRACL-seq for label-free enrichment of rare cell types by...

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Identifiers

PMID: 32888429
DOI: 10.1016/j.cell.2020.08.003
PMCID: PMC8358727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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