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Article

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

5 Feb 2019

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness. Median survival after symptom onset in patients is 3-5 years and no effective therapies are available to treat or cure ALS. Therefore, further insight is needed into the molecular and cellular mechanisms that cause motor neuron...

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PMID: 30721407
DOI: 10.1007/s00401-019-01964-7

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