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Article

Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology.

Acta neuropathologica - 1 Dec 2011

Ince Paul G, Highley J Robin, Kirby Janine, Wharton Stephen B, Takahashi Hitoshi, Strong Michael J, Shaw Pamela J

Abstract excerpt

Research into amyotrophic lateral sclerosis (ALS) has been stimulated by a series of genetic and molecular pathology discoveries. The hallmark neuronal cytoplasmic inclusions of sporadic ALS (sALS) predominantly comprise a nuclear RNA processing protein, TDP-43 encoded by the gene TARDBP, a discovery that emerged from high throughput analysis of human brain tissue from patients with frontotemporal dementia (FTD)...

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Source

Identifiers

PMID: 22105541
DOI: 10.1007/s00401-011-0913-0

Genes

FUS
TARDBP
SOD1
VAPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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