Article

Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

2020-09-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability of stem cells and promotes proliferation. Graves’ ophthalmopathy (GO) is an autoimmune inflammatory disease of the orbit and is characterized by increased orbital levels of adipose tissue. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6bfc906d-c0f8-53a1-9e6f-c904a8e7b588
DOI: 10.21203/rs.2.23922/v4

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathyDOI 10.21203/rs.2.23922/v4Read

TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated OphthalmopathySemantic proximity Read

MicroRNA-27 inhibits adipogenic differentiation in orbital fibroblasts from patients with Graves’ orbitopathySemantic proximity Read

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy.Semantic proximity Read

Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model.Semantic proximity Read

The Orbital Fibroblast: A Key Player and Target for Therapy in Graves’ OphthalmopathySemantic proximity Read

Transcriptomic profiling of human orbital fat and differentiating orbital fibroblastsSemantic proximity Read

Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments.Semantic proximity Read

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R PathwaySemantic proximity Read

Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathwaySemantic proximity Read

Unravelling the pathogenic mechanisms in Graves’ orbitopathySemantic proximity Read

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.Semantic proximity Read

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy.Semantic proximity Read