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Article

Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model.

Endocrinology - 1 Oct 2016

Görtz Gina-Eva, Moshkelgosha Sajad, Jesenek Christoph, Edelmann Bärbel, Horstmann Mareike, Banga J Paul, Eckstein Anja, Berchner-Pfannschmidt Utta

Abstract excerpt

A mouse model of Graves' orbitopathy (GO) induced by genetic immunization of human TSH receptor (TSHR) A-subunit encoding plasmid has recently been established. The orbital pathology was characterized by adipogenesis, myopathy and fibrosis. Human orbital fibroblasts (OFs) express TSHR and IGF-1 receptor (IGF-1R) and are considered to be pathogenic in GO. We established conditions for growing ex vivo cultures of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27552248
DOI: 10.1210/en.2016-1304

Genes

TSHR

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