Back to search

Article

TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy

2022-03-28

Abstract excerpt

<title>Abstract</title> <p>Background Thyroid-associated ophthalmopathy (TAO) includes several ocular manifestations of the systemic autoimmune process, Graves’ disease. The key pathogenic cells are orbital fibroblasts (OFs). The OFs of most TAO patients are differentiated from pre-adipocytes to mature adipocytes, increased lipid and fat expansion are characteristic of ophthalmic disease. Human placental mesench...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8a9e0b48-e40c-5b97-9eda-cc8cd1691537
DOI
10.21203/rs.3.rs-1476037/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated OphthalmopathyDOI 10.21203/rs.3.rs-1476037/v1
Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathySemantic proximity
MicroRNA-27 inhibits adipogenic differentiation in orbital fibroblasts from patients with Graves’ orbitopathySemantic proximity
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy.Semantic proximity
IL-17A Promotes RANTES Expression, But Not IL-16, in Orbital Fibroblasts Via CD40-CD40L Combination in Thyroid-Associated OphthalmopathySemantic proximity
Transcriptomic profiling of human orbital fat and differentiating orbital fibroblastsSemantic proximity
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathwaySemantic proximity
Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model.Semantic proximity
IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy.Semantic proximity
Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.Semantic proximity
Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R PathwaySemantic proximity
Exploring the Role of SRC in Extraocular Muscle Fibrosis of the Graves’ OphthalmopathySemantic proximity
Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathwaySemantic proximity
Select a neighboring publication to make it the new centre.