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Article

The Orbital Fibroblast: A Key Player and Target for Therapy in Graves’ Ophthalmopathy

1 Aug 2010

Abstract excerpt

Orbital fibroblasts play a key role in the pathogenesis of Graves' ophthalmopathy (GO). We discuss some major aspects by which orbital fibroblasts contribute to GO and the important role of PDGF-BB herein. Finally, we propose the orbital fibroblast, and especially the PDGF system acting on orbital fibroblasts, as an important therapeutic target in GO.

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Identifiers

PMID: 20812837
DOI: 10.3109/01676831003668443

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Related research

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