Article

Analysis of Genetic Association Studies Incorporating Prior Information of Genetic Models

2015-06-01

Abstract excerpt

In genetic association studies, for each underlying genetic model, there is an optimal test. Usually, the true model is unknown, but knowledge from previous genome-wide association studies for the disease under investigation is available and provides information about the underlying model. We study how to incorporate this prior information about plausible genetic models to achieve better efficiency robustness in g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6bf201b4-fb54-58ca-921d-ae25d805c68b
DOI: 10.1007/s13253-015-0200-y

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of Genetic Association Studies Incorporating Prior Information of Genetic ModelsDOI 10.1007/s13253-015-0200-yRead

A robust method for testing association in genome-wide association studies.Semantic proximity Read

Genetic model selection in two-phase analysis for case-control association studies.Semantic proximity Read

Improving power for testing genetic association in case-control studies by reducing the alternative space.Semantic proximity Read

Bayes factor based on the trend test incorporating Hardy-Weinberg disequilibrium: more power to detect genetic association.Semantic proximity Read

Genetic risks and genetic model specification.Semantic proximity Read

A robust test for two-stage design in genome-wide association studies.Semantic proximity Read

Genomic control for association studies under various genetic models.Semantic proximity Read

Strategies for genetic model specification in the screening of genome-wide meta-analysis signals for further replication.Semantic proximity Read

Pearson's test, trend test, and MAX are all trend tests with different types of scores.Semantic proximity Read

A unifying framework for robust association testing, estimation, and genetic model selection using the generalized linear model.Semantic proximity Read

Robust Mantel-Haenszel test under genetic model uncertainty allowing for covariates in case-control association studies.Semantic proximity Read

[Choice of genetic model on Meta-analysis of genetic association studies: introduction of genetic model-free approach for Bayesian analysis].Semantic proximity Read