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Article

Robust Mantel-Haenszel test under genetic model uncertainty allowing for covariates in case-control association studies.

Genetic epidemiology - 1 Nov 2011

Zang Yong, Fung Wing Kam

Abstract excerpt

The trend test under the additive model is commonly used when a case-control genetic association study is carried out. However, for many complex diseases, the underlying genetic models are unknown and a mis-specification of the genetic model may result in a substantial loss of power. MAX3 has been proposed as an efficiency robust test against genetic model uncertainty which takes the maximum absolute value of the...

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PMID: 22009791
DOI: 10.1002/gepi.20620

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