Article

Cancer Cell Line Heterogeneity Imposes a Primary Bottleneck for Virtual Perturbation Screening at Scale

2026-08-15

Abstract excerpt

UniPert-G2CP (Li et al., Cell, 2026) bridges genetic and chemical screens from molecular representation to phenotype modeling across five cancer cell lines [1]. Here we extend this architecture to 162 cell lines, 32,039 compounds, and genome-wide output (12,328 genes), and find that the resulting prediction platform reveals a striking performance divide: normal and primary cell lines achieve substantially higher p...

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Literature Corpus work: 6bc97f64-c72d-5206-a577-301b1384f6d2
DOI: 10.64898/2026.08.10.743942

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