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Article

Neural hyperactivity is a core pathophysiological change induced by deletion of an autism risk gene <i>Ash1l</i> in the mouse brain

2022-01-20

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental disease associated with various gene mutations. Previous genetic and clinical studies report that mutations of the epigenetic gene ASH1L are highly associated with human ASD and intellectual disability (ID). Recent studies demonstrate that loss of Ash1l in the mouse brain is sufficient to induce ASD/ID-like behavioral and cognitive memory deficits, suggestin...

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Literature Corpus work
6bc6bf4c-c178-5d04-b3f5-78571d80a449
DOI
10.1101/2022.01.19.476965
Open publication

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Neural hyperactivity is a core pathophysiological change induced by deletion of an autism risk gene <i>Ash1l</i> in the mouse brainDOI 10.1101/2022.01.19.476965
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