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Article

BCL2 mutation spectrum in B-cell non-Hodgkin lymphomas and patterns associated with evolution of follicular lymphoma.

Hematological oncology - 1 Mar 2015

Burkhard Regula, Bhagat Govind, Cogliatti Sergio B, Rossi Davide, Gaidano Gianluca, Pasqualucci Laura, Novak Urban

Abstract excerpt

BCL2 is a target of somatic hypermutation in t(14;18) positive and also in a small fraction of t(14;18) negative diffuse large B-cell lymphoma (DLBCL), suggesting an aberrant role of somatic hypermutation (ASHM). To elucidate the prevalence of BCL2 mutations in lymphomas other than DLBCL, we Sanger-sequenced the hypermutable region of the BCL2 gene in a panel of 69 mature B-cell lymphomas, including Richter's...

Topics

Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA Mutational Analysis
Gene Frequency
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell
Lymphoma, Follicular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-2

Regulatory Sequences, Nucleic Acid

Translocation, Genetic

Source

Identifiers

PMID: 24496723
DOI: 10.1002/hon.2132

Genes

BCL2

Provenance

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