Article

Human GPR174 deficiency drives polyclonal lymphoproliferative disease via defects in T cell function

2026-07-17

Abstract excerpt

The X-linked G-protein coupled receptor GPR174 is highly expressed in T and B lymphocytes and has immunoregulatory roles in mice, but its function in humans is unknown. We describe a cohort of six individuals who have function-disrupting variants in GPR174 and a clinical phenotype of lymphadenopathy and autoimmunity. Histological analysis of two patient lymph nodes revealed necrotizing lymphadenitis and lymphopro...

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Literature Corpus work: 6bb27c0a-1a5b-5d5e-b758-13ef7eeeda1f
DOI: 10.64898/2026.07.14.26357774

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