Article

Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material

2005-10-24

Abstract excerpt

We here addressed the basic question, how does extrachromosomal DNA behave when it is placed in the nuclear or the cytoplasmic environment and how is it eliminated? To do this, we tracked microinjected DNA molecules in live cells. In the cytoplasm, the diffusion of microinjected DNA was inhibited in a size- and linearity-dependent manner, probably by the intermediate filament. This was followed by the rapid disapp...

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Literature Corpus work: 6b733c63-3569-59df-83cd-0ab058cec2fe
DOI: 10.1093/nar/gki946

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