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Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering

1 Jan 2001

Abstract excerpt

Mitotic chromosome segregation is mediated by spindle microtubules attached to centromeres. Recent studies, however, revealed that acentric DNA molecules, such as viral replicons and double minute chromosomes, can efficiently segregate into daughter cells by associating with mitotic chromosomes. Based on this similarity between viral and cellular acentric molecules, we introduced Epstein-Barr virus vectors into...

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PMID: 11112689
DOI: 10.1242/jcs.114.1.49

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