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Article

Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase.

Communications biology - 20 Jan 2022

Haraguchi Tokuko, Koujin Takako, Shindo Tomoko, Bilir Şükriye, Osakada Hiroko, Nishimura Kohei, Hirano Yasuhiro, Asakawa Haruhiko, Mori Chie, Kobayashi Shouhei, Okada Yasushi, Chikashige Yuji, Fukagawa Tatsuo, Shibata Shinsuke, Hiraoka Yasushi

Abstract excerpt

DNA transfection is an important technology in life sciences, wherein nuclear entry of DNA is necessary to express exogenous DNA. Non-viral vectors and their transfection reagents are useful as safe transfection tools. However, they have no effect on the transfection of non-proliferating cells, the reason for which is not well understood. This study elucidates the mechanism through which transfected DNA enters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35058555
DOI: 10.1038/s42003-022-03021-8
PMCID: PMC8776997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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