Article
Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein.
Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014
Chen Jianbo, Grunwald David, Sardo Luca, Galli Andrea, Plisov Sergey, Nikolaitchik Olga A, Chen De, Lockett Stephen, Larson Daniel R, Pathak Vinay K, Hu Wei-Shau
Abstract excerpt
Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1 RNA is transported within the cytoplasm remains undefined. Full-length HIV-1 RNA transport is further complicated when...
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