Article

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism

2021-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Adipose tissue (AT) plays a crucial role in maintaining me tabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like AT become insulin resistant, decompensation of blood glucose levels occurs causing type 2 diabetes (T2D). Currently, glycocalyx modulating as a pharmacological treatment strategy to improve glucose homeostasis in T2D patien...

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Literature Corpus work: 6b13e6c8-414b-59a2-b97c-b6ac7414d3a2
DOI: 10.1101/2021.07.08.451710

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